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Foxa2

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Title: Foxa2  
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Subject: Hepatocyte nuclear factors, NeuroD, EMX homeogene, NOBOX, Nur (biology)
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Foxa2

Forkhead box A2
Identifiers
Symbols  ; HNF3B; TCF3B
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is a protein that in humans is encoded by the FOXA2 gene.[1][2][3]

Function

Forkhead box protein A2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.[1]

References

  1. ^ a b "Entrez Gene: forkhead box A2". 
  2. ^ Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics 39 (3): 417–9.  
  3. ^ Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M, Wollheim CB (May 2002). "Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release". J. Biol. Chem. 277 (20): 17564–70.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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