World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0004401715
Reproduction Date:

Title: Burimamide  
Author: World Heritage Encyclopedia
Language: English
Subject: Metiamide, H2 antagonist, Histamine H3 receptor, Histaminergic, Betazole
Publisher: World Heritage Encyclopedia


Skeletal formula
Space-filling model
CAS number  YesY
ChemSpider  YesY
Jmol-3D images Image 1
Molecular formula C9H16N4S
Molar mass 212.32 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

Burimamide is an antagonist at the H2 and H3 histamine receptors. It is largely inactive as an H2 antagonist at physiological pH,[1] but its H3 affinity is 100x higher. It is a thiourea derivative.

Burimamide was first developed by scientists at Smith, Kline & French (SK&F; now GlaxoSmithKline) in their intent to develop a histamine antagonist for the treatment of peptic ulcers.[2] The discovery of buriamide ultimately led to the development of cimetidine (Tagamet).[2]

See also


  1. ^  
  2. ^ a b -receptor Antagonists"2: Discovery of Histamine H®"Tagamet. National Historic Chemical Landmarks. American Chemical Society. Retrieved June 25, 2012. 
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.