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Title: Chlorophenylbiguanide  
Author: World Heritage Encyclopedia
Language: English
Subject: RS-56812, BRL-54443, 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide, PNU-22394, SB-215505
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS number
ATC code ?
ChemSpider  YesY
Chemical data
Formula C8H12ClN5 
Mol. mass 213.667 g/mol

Chlorophenylbiguanide (1-(3-Chlorophenylbiguanide, m-CPBG) is an agonist for the 5HT3 receptor and an antagonist for the Alpha-2A adrenergic receptor.[1] It has anxiogenic, emetic and hypothermic effects in animal studies.[2][3][4][5]


  1. ^ Schlicker E, Kathmann M, Exner HJ, Detzner M, Göthert M (1994). "the 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide facilitates noradrenaline release by blockade of alpha 2-adrenoceptors in the mouse brain cortex". Naunyn-Schmiedeberg's archives of pharmacology 349: 20–24.  
  2. ^ Andrews N, File SE (1992). "Are there changes in sensitivity to 5-HT3 receptor ligands following chronic diazepam treatment?". Psychopharmacology 108 (3): 333–7.  
  3. ^ Dukat M, Young R, Darmani NN, Ahmed B, Glennon RA (June 2000). "The 5-HT3 agent N-(3-chlorophenyl)guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis assay". Psychopharmacology 150 (2): 200–7.  
  4. ^ Castro L, Varjão B, Maldonado I, Campos I, Duque B, Fregoneze J, Reis de Oliveira I, De Castro-e-Silva E (November 2002). "Central 5-HT(3) receptors and water intake in rats". Physiology & Behavior 77 (2-3): 349–59.  
  5. ^ Naumenko VS, Kondaurova EM, Popova NK (November 2009). "Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor". Neuroscience Letters 465 (1): 50–4.  

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