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Title: Conessine  
Author: World Heritage Encyclopedia
Language: English
Subject: Histamine H3 receptor
Publisher: World Heritage Encyclopedia


CAS number 546-06-5 YesY
PubChem 2860
MeSH Conessine
Jmol-3D images Image 1
Molecular formula C24H40N2
Molar mass 356.5878
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Conessine is a steroid alkaloid found in a number of plant species from the Apocynaceae family, including Holarrhena floribunda,[1] Holarrhena antidysenterica[2] and Funtumia elastica,[3] several of which are used in traditional herbal medicine as a treatment for amoebic dysentery.[4] It acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi=8.27; Ki~5nM).[5] It was also found to have long CNS clearance times, high blood-brain barrier penetration and high affinity for the adrenergic receptors.[6]


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