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Title: Dipivefrine  
Author: World Heritage Encyclopedia
Language: English
Subject: Apraclonidine, Carteolol, Guanethidine, Brimonidine, Clonidine
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
[2-(2,2-dimethylpropanoyloxy)-4- (1-hydroxy-2-methylamino-ethyl)- phenyl] 2,2-dimethylpropanoate
Clinical data
Trade names Propine
  • US: B (No risk in non-human studies)
CAS Registry Number  Y
ATC code S01
PubChem CID:
DrugBank  Y
ChemSpider  Y
Chemical data
Formula C19H29NO5
Molecular mass 351.437 g/mol

Dipivefrin (trade name Propine) is a prodrug of epinephrine, and is used to treat open-angle glaucoma.[1] It is available as a 0.1% ophthalmic solution.

Mechanism of action

The drug when applied over the cornea, penetrates it and is then hydrolysed to epinephrine by the esterases. It increases uveosacral outflow and also reduces aqueous formation (an α1 and α2 mediated action), thus reducing the intraocular pressure. It also increases the hydraulic conductivity of trabecular filtering cells (a β2 mediated action). It is preferred to epinephrine because it is longer acting, more consistent in its action and has better ocular tolerance.[1]


  1. ^ a b KD Tripari MD. Essentials of Medical Pharmacology (5 ed.). Jaypee Brothers Medical Publishers(P) Ltd. p. 88.  
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