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Drug-induced hyperthermia

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Drug-induced hyperthermia

Drug-induced fever is a state wherein the administration of drugs intended to help a patient causes a hypermetabolic state resulting in fever. The drug may interfere with heat dissipation peripherally, increase the rate of metabolism, evoke a cellular or humoral immune response, mimic endogenous pyrogen, or damage tissues.

Triggers


Clinical Treatment

The primary treatment strategy is to eliminate or discontinue the offensive agent. Supportive therapy, such as ice packs, may be provided to get the body temperature within physiologic range. In severe cases, when the fever is high enough (generally at or above ~104.° F), aggressive cooling such as an ice bath and pharmacologic therapy such as benzodiazepines may be deemed appropriate.[1]

External links

Tabor PA (June 1986). "Drug-induced fever". Drug Intell Clin Pharm 20 (6): 413–20.  

  1. ^ Diagnosis and treatment of drug-induced hyperthermia. Musselman, ME. Saely, S. doi: 10.2146/ajhp110543 American Journal of Health-System Pharmacy January 1, 2013 vol. 70 no. 1 34-42
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