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Title: Gpr56  
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Subject: Bilateral frontoparietal polymicrogyria, BFPP
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G protein-coupled receptor 56
GPR56 Gene
RNA expression pattern

G-protein coupled receptor 56 is a protein that in humans is encoded by the GPR56 gene. The gene product is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[1][2] [3][4][5][6] GPR56 has been shown to have numerous role in cell guidance/adhesion as exemplified by its roles in tumour inhibition and neuron development,.[7][8] More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of Natural killer cells[9]

In melanocytic cells GPR56 gene expression may be regulated by MITF.[10]


External links

  • GeneReviews/NIH/NCBI/UW entry on Polymicrogyria Overview

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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