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Invasive lobular carcinoma

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Title: Invasive lobular carcinoma  
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Subject: Medullary carcinoma of the breast, Breast cancer, Comedocarcinoma, Intraductal papilloma, CDH1 (gene)
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Invasive lobular carcinoma

Invasive lobular carcinoma
Classification and external resources
Invasive lobular carcinoma demonstrating a predominantly lobular growth pattern
ICD-O: M8520/3
Lobular breast cancer. Single file cells and cell nests.

Invasive lobular carcinoma accounts for 5-10% of invasive breast cancer.[1][2]

The histologic patterns include:[3] [4][5]
Type Prevalence Description
Classical 40% round or ovoid cells with little cytoplasm in a single-file infiltrating pattern, sometimes concentrically giving a targetoid pattern
Alveolar 5% Aggregates of classical-appearing cells
Solid 10% Sheets of classical-appearing cells with little intervening stroma
Tubulolobular 5% Cells form microtubules in >90% of tumor (smaller than in tubular carcinoma)
Pleomorphic Classical-appearing but with pleomorphic cells
Mixed 40% No dominant pattern

Overall, the five-year survival rate of invasive lobular carcinoma was approximately 85% in 2003.[6]

Loss of E-cadherin is common in lobular carcinoma but is also seen in other breast cancers.[7]

Treatment includes surgery and adjuvant therapy.


  1. ^ Pointon KS, Cunningham DA (August 1999). "Ultrasound findings in pure invasive lobular carcinoma of the breast: comparison with matched cases of invasive ductal carcinoma of the breast". Breast 8 (4): 188–90.  
  2. ^ Boughey JC, Wagner J, Garrett BJ, et al (March 2009). "Neoadjuvant Chemotherapy in Invasive Lobular Carcinoma May Not Improve Rates of Breast Conservation". Ann. Surg. Oncol. 16 (6): 1606–11.  
  3. ^ Moore MM, Borossa G, Imbrie JZ, et al (June 2000). "Association of Infiltrating Lobular Carcinoma With Positive Surgical Margins After Breast-Conservation Therapy". Ann. Surg. 231 (6): 877–82.  
  4. ^ Spencer JT, Shutter J (March 2009). "Synchronous bilateral invasive lobular breast cancer presenting as carcinomatosis in a male". Am. J. Surg. Pathol. 33 (3): 470–4.  
  5. ^ Fletcher's diagnostic histopathology of tumors. 3rd Ed. p. 931-932.
  6. ^ Arpino G, Bardou VJ, Clark GM, Elledge RM (2004). "Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome". Breast Cancer Res. 6 (3): R149–56.  
  7. ^ Varga Z, Mallon E. (Oct 2009). "Histology and Immunophenotype of Invasive Lobular Breast Cancer. Daily Practice and Pitfalls". Breast Dis. 30: 15–19.  
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