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Title: L-745,870  
Author: World Heritage Encyclopedia
Language: English
Subject: List of dopaminergic drugs, Nafadotride, SKF-89,145, AS-8112, CY-208,243
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS number  YesY
ATC code ?
ChemSpider  N
Chemical data
Formula C18H19ClN4 
Mol. mass 326.822 g/mol

L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.[1][2][3]


  1. ^ Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist". Trends in Pharmacological Sciences 18 (6): 186–8.  
  2. ^ Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004). "Regulation of working memory by dopamine D4 receptor in rats". Neuropsychopharmacology 29 (9): 1648–55.  
  3. ^ Moustgaard A, Hau J, Lind NM (2008). "Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats". Behavioral and Brain Functions 4: 49.  

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