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Title: Mebeverine  
Author: World Heritage Encyclopedia
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Subject: Isopropamide, Cinitapride, Fedotozine, Cholinergics, WIN-2299
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Systematic (IUPAC) name
(RS)-4-(ethyl[1-(4-methoxyphenyl)propan-2-yl]amino)butyl 3,4-dimethoxybenzoate
Clinical data
Trade names Colofac, Duspamen and others
Legal status
Routes Oral
CAS number  YesY
ATC code A03
ChemSpider  YesY
Chemical data
Formula C25H35NO5 
Mol. mass 429,6[g/mol]

Mebeverine is a Abbott Laboratories.

Mebeverine (Colofac) 135 mg, U.K.


Spastic functional disturbances of the colon:

  • Irritable bowel syndrome in its primary form
  • Irritable bowel syndrome associated with organic lesions of the gastrointestinal tract such as; diverticulosis and diverticulitis, regional enteritis, disease of the gall bladder and gall ducts, gastric and duodenal ulcers, dysentery, and aspecific or specific inflammation of the digestive tract.
  • Mebeverine should be taken 20 minutes before meals.

Mechanism of action

Mebeverine is an antimuscarinic. It belongs to a group of compounds called musculotropic antispasmodics. These compounds act directly on the gut muscles at the cellular level to relax them. This relieves painful muscle spasms of the gut, without affecting its normal motility. Mebeverine is used to relieve symptoms of irritable bowel syndrome and related intestinal disorders that are the result of spasms in the intestinal muscles. These include colicky abdominal pain and cramps, diarrhoea alternating with constipation and flatulence (wind).

Mebeverine is also an inhibitor of calcium-depot replenishment. Therefore, it has dual mode of action which normalizes the small bowel motility.

Adverse effects

Side effects may include:[1]

  • Indigestion or heartburn
  • Constipation
  • Dizziness
  • Insomnia (difficulty sleeping)
  • anorexia (loss of appetite)
  • Headache
  • Tiredness
  • Slow heart beat
  • Rash and/or itchy skin

Since 1978, 21 cases of severe adverse reactions to mebeverine were reported in the Netherlands.[2] Most reactions consisted of urticaria or maculopapular rash, sometimes accompanied by fever, polyarthritis, thrombopenia or angioedema.

Very rarely, people taking this medicine may develop allergic reactions.[3]

Pregnancy and breastfeeding

Mebeverine passes into breast milk, but the amount is considered too small to be harmful to a nursing infant.[1]

Driving and using machines

Mebeverine is unlikely to affect the ability to operate machinery or to drive, yet not completely out of the question. [4] [5]


  1. ^ a b Colofac Data Sheet (PDF)
  2. ^ in 't Veld BA, van Puyenbroek E, Stricker BH. (1997). Hypersensitivity reactions to use of mebeverine. pp. 1392–5.  Ned Tijdschr Geneeskd. 1997 July 12;141(28):1392-5. Hypersensitivity reactions to use of mebeverine [1] pubmed: 9380201
  3. ^ Colofac Patient leaflet sheet
  4. ^
  5. ^

External links

  • Drug Leaflet
  • Colofac official site
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