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Ru-24,969

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Title: Ru-24,969  
Author: World Heritage Encyclopedia
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Subject: 5-HT1A receptor, RS-56812, MPPF, 9-Aminomethyl-9,10-dihydroanthracene, 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
Collection: Phenol Ethers, Serotonin Receptor Agonists
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Ru-24,969

RU-24,969
Systematic (IUPAC) name
5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
PubChem
ChemSpider  N
Chemical data
Formula C14H16N2O 
Mol. mass 228.289 g/mol
 N   

RU-24,969 is a drug and research chemical widely used in scientific studies. It is a selective agonist at the 5-HT1A and 5-HT1B receptors, with preference for the latter.[1] As with other 5-HT1B agonists such as CP-94,253, RU-24,969 has been found to increase the reinforcing properties of cocaine, suggesting a role for 5-HT1B receptors in cocaine addiction.[2]

See also

References

  1. ^ Doods HN, Kalkman HO, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, Van Zwieten PA. (1985). "Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity.". Eur J Pharmacol. 112 (3): 363–370.  
  2. ^ Parsons LH, Weiss F, Koob GF (December 1998). "Serotonin1B receptor stimulation enhances cocaine reinforcement". Journal of Neuroscience 18 (23): 10078–89.  


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