World Library  
Flag as Inappropriate
Email this Article

Infobox drug/sandbox

Article Id: WHEBN0021317015
Reproduction Date:

Title: Infobox drug/sandbox  
Author: World Heritage Encyclopedia
Language: English
Publisher: World Heritage Encyclopedia

Infobox drug/sandbox

Infobox drug/sandbox
Template documentation

provides a consistent layout for drug articles and an interface to other sources that provide information about the drug. It can be used for single drugs, combination products (see #Combination products), monoclonal antibodies (see #Monoclonal antibody drugs) and vaccines (see #Vaccines). Don't worry about trying to fill in all the fields – even specifying just one or two can be useful.


  • Single chemical drugs 1
  • Combination products 2
  • Monoclonal antibody drugs 3
  • Vaccines 4
  • Parameter notes 5
    • Names 5.1
    • Images 5.2
    • Clinical data 5.3
      • Pregnancy category 5.3.1
      • Legal status 5.3.2
      • Dependence liability 5.3.3
      • Licensing information 5.3.4
    • Pharmacokinetic data and routes of administration 5.4
    • Names and identifiers 5.5
      • DrugBank 5.5.1
      • PubChem 5.5.2
      • ATC, ATCvet and CAS 5.5.3
      • Verification and |CAS_number_Ref= like parameters 5.5.4
    • Chemical data 5.6
      • Chemical formula 5.6.1
      • Other chemical data 5.6.2
      • Physical data 5.6.3
  • Section overview by |type= options 6
  • Maintenance categories 7
  • See also 8

Single chemical drugs

While editing a drug page, copy and paste either style of the following text at the top of the page:

Shortened single-drug form:

Full single-drug template with extended fields:

OR alternatively: use Diberri's excellent WorldHeritage template filling tool which will generate a populated template to copy & paste into an article if given a DrugBank ID number (which may be obtained from DrugBank search). Please select for Fill template vertically, but as WorldHeritage is a general encyclopedia, most drugs do not warrant Show extended fields.

Combination products

Set the parameter type=combo. This form of the box uses a different subset of parameters. For drug-combinations, at least two components must be defined, with optional 3rd or 4th components. For each component:

  • define its name (which will be automatically wikilinked)
  • and the class of agent it belongs to but this usually needs manual wikilinking, e.g. for Seretide:
Combination of
Fluticasone Glucocorticoid
Salmeterol Long-acting beta2 agonist
| type       = combo
| drug_name  = Seretide
| component1 = Fluticasone
| class1     = 
| component2 = Salmeterol 
| class2     = 

Generally combination articles will not need to display the molecular images of its constituents (the relevant specific articles would have the images). It disables all Chemical & Pharmacology parameters (which describe properties of single drug items). These redundant disabled parameters are best not included in the template calling, so use the following abridged forms of the template:

Shortened combination product form:

| component2        = 
| class2            = 

| pronounce         =
| tradename         = 
|         = 
| MedlinePlus       = 
| pregnancy_AU      = 
| pregnancy_US      = 
| pregnancy_category= 
| legal_AU          = 
| legal_AU_comment =
| legal_CA = 
| legal_UK = 
| legal_US = 
| legal_UN = 
| legal_NZ = 
| legal_status      = 
| routes_of_administration = 

| CAS_number        = 
| ATCvet            = 
| ATC_prefix        = 
| ATC_suffix        = 
| PubChem           = 
| DrugBank          = 

Full combination product template with extended fields and allowing for up to 4 items:

| component2        = 
| class2            = 
| component3        = 
| class3            = 
| component4        = 
| class4            = 

| pronounce         =
| tradename         = 
|         = 
| MedlinePlus       = 
| licence_EU        = 
| licence_US        = 
| DailyMedID        = 
| pregnancy_AU      = 
| pregnancy_US      = 
| pregnancy_category= 
| legal_AU = 
| legal_AU_comment =
| legal_CA = 
| legal_UK = 
| legal_US = 
| legal_status      = 
| dependency_liability = 
| addiction_liability = 
| routes_of_administration = 

| CAS_number        = 
| CAS_supplemental  = 
| ATCvet            = 
| ATC_prefix        = 
| ATC_suffix        = 
| ATC_supplemental  = 
| PubChem           = 
| PubChemSubstance  = 
| IUPHAR_ligand     = 
| DrugBank          = 
| ChemSpiderID      = 
| UNII              = 
| KEGG              = 
| ChEBI             = 
| ChEMBL            = 
| synonyms          = 

Monoclonal antibody drugs

Set the parameter type=mab. This form of the box uses a different subset of parameters, mab_type, source and target:

Monoclonal antibody
Type Trifunctional antibody
Source Rat/mouse hybrid
Target EpCAM, CD3
| type       = mab
| drug_name  = Catumaxomab
| mab_type   = 3funct
| source     = axo
| target     = , 
mab_type defines one of the following types of antibody or antibody fragment:
mab_type output
mab Whole antibody
Fab Fab fragment
F(ab')2 F(ab')2 fragment
Fab' Fab' fragment
scFv Single-chain variable fragment
di-scFv Di-single-chain variable fragment
3funct Trifunctional antibody
clFab Chemically linked Fab
BiTE Bi-specific T-cell engager
source is the species on which the protein sequence of the antibody is based:
source output
a Rat
e Hamster
i Primate
o Mouse
u Human
xi/a, xi/e, etc. Chimeric (rat/human) etc.
xi Chimeric [generic, use only if values above are not applicable]
zu/a, zu/e, etc. Humanized (from rat) etc.
zu Humanized [generic, use only if values above are not applicable]
xizu/a, xizu/e, etc. Chimeric/humanized hybrid (rat/human) etc.
xizu Chimeric/humanized hybrid [generic, use only if values above are not applicable]
axo Rat/mouse hybrid

target is the antigen at which the antibody is directed. This parameter takes free text as value, preferably including a wikilink such as target = .

The drug name is followed by a "?" linked to Nomenclature of monoclonal antibodies, saving the need to explain how each monoclonal antibody has been named.

Shortened Monoclonal antibody form:

Full Monoclonal antibody template with extended fields:


Set the parameter type=vaccine. This allows the alternative parameters of the vaccine_type and target to be specified:

  • target is freetext. Usually will be wikified by the editor to point to a specific page
  • vaccine_type must be from the defined list of options as described at Vaccine#Types, the infobox will provide standardised display and links as follows:
vaccine_type value Output
killed or inactivated Killed/Inactivated
attenuated Attenuated virus
live Live bacteria
toxoid Toxoid
protein or protein subunit Protein subunit
subunit Subunit
conjugate Conjugate vaccine
recombinant Recombinant Vector
DNA DNA vaccination

Where a vaccination product protects against more than one agent, please use the combination form of this infobox with type=combo (per #Combination products), and each classX=.

Shortened Vaccine form:

Full Vaccine template with extended fields:

Parameter notes


| drug_name = 
| IUPAC_name = 
| tradename = 
| synonyms = 
See #Names and identifiers


You can use the image to provide an illustration. These fields are optional, but it is helpful to provide an image if you can find one. Of course most images on the internet are copyrighted.

You may specify the image name directly, else the template defaults to trying to use File:PAGENAME.png, where PAGENAME is the name of the drug article being written.

The alt parameter specifies the alt text for the image, used by visually impaired readers. See WorldHeritage:ALT.

There is also an optional width parameter you can add for the image. If your picture is far too big, then add a new line and specify a custom width like this:

 | image            = Aspirin.png
 | width            = 325

When no width parameter is specified, it defaults to a width of 220.

Occasionally a second image might be added to show the chemical structure in a different format. Use the optional image2 parameter for this. Hence the Paracetamol article uses:

 | image            = Paracetamol-skeletal.png 
 | image2           = Paracetamol-3D.png

An alt2 parameter specifies the alt text for the second image. image2 generally uses the same width settings as the first image, i.e. as defined by width otherwise a default value of 220. A specific width2 may though be applied.

| image = 
| width = 
| alt = 
| image2 = 
| width2 = 
| alt2 = 
| caption = 
| imageL = 
| widthL = 
| altL = 
| imageR=
| widthR = 
| altR = 
| captionLR = 

Clinical data

| tradename =  
| =
| MedlinePlus =
  • tradename – comma separated list of tradenames
  • – link to monograph
  • MedlinePlus – MedlinePlus drug accession number
Pregnancy category
See also for extensive documentation

Pregnancy Categorisation has been previously declared using just the pregnancy_category parameter with a variety of markup styles used to indicate various countries and their classifications. Alternatively pregnancy_AU and pregnancy_US may be set to the fixed categories. For Australia values permitted are: A, B1, B2, B3, C, D or X (note if just set to 'B' then B? is shown). For US values permitted are: A, B, C, D or X.

Note the UK does not have official designated categorisations, but has both a variety of standard phrases with explanatory qualifications, plus many individual descriptions. The generic |pregnancy_category= acceptts any text, and may be used with such country-specific information (non AU or US).

For the new US labeling guidelines PLLR, parameter |PLLR= is added and will show any input text (not re-formatted). Hence

  | pregnancy_AU = B1
  | pregnancy_AU_comment = any text
  | pregnancy_US = C
  | pregnancy_US_comment = any text
  | pregnancy_category = Used in pregnancy against 
  | PLLR = Some PLLR text


  • AU: B1 any text
  • US: C (Risk not ruled out) any text
  • US PLLR: Some PLLR text
  • Used in pregnancy against PIH
Legal status
See also: for extensive documentation.

Legal status has been previously declared using just the legal_status parameter with a variety of markup styles used to indicate various countries and their classifications. Alternatively legal_AU, legal_EU legal_CA, legal_NZ, legal_UK, legal_UN, and legal_US may be set to the fixed options in the table hereafter. The template will ensure the categorisation is shown correctly capitalised, use Unicode Rx symbol and add a linked 2-letter country code as per WorldHeritage:MOS. legal_status may still be used with the country-specific parameters as it is appended afterwards, allowing backwards compatibility for articles that only define this parameter, or for the future with free-text of other information.


| legal_AU     = S2
| legal_AU_comment = any text
| legal_CA     = 
| legal_UK     = gsl
| legal_US     = Rx-only
| legal_EU     =
| legal_UN     =
| legal_NZ     = 
| legal_status = Not marketed in 


Note: if a drug is restricted everywhere to prescription-only, please set legal_status = Rx-only rather than similarly define for each and every country ('Rx-only' is specifically recognised by legal_status and shows as Prescription only)

Dependence liability

Optional parameters Dependence liability and Addiction_liability allow opioids or benzodiazepines to be flagged with the risk of becoming dependent/addicted upon them, although in many cases this may be somewhat subjective. Drugs should be rated as Low, Medium, High or Extremely high:

| dependency_liability = High
| addiction_liabiliy = High
Licensing information

There are two major licensing authorities that make drug information easily accessible: The US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). NB: The word "licence" is the noun in British English, "license" is the verb.

The FDA "Label Information" and the EMA "Product Information", where available, are very detailed. There is material aimed at the professional and also plain-English consumer information. These are excellent reliable source for article information but also contains much that makes it a worthwhile "External link" since there is no way one can include all the info. Both sites work using of the brand name of the drug but the FDA site also allows searches with the generic name (active ingredient), which lists generic variants where they are licensed.

| licence_EU =  
| licence_US =   

Lists of products and the parameter term to use may be easily searched for:

  • European Public Assessment Reports: SiteMap, authorised products A–Z: human, veterinary
    When items are composed of more than one word, licence_EU uses adjoined words (i.e. no spaces); e.g. infanrixpenta for Infanrix Penta.
  • Drugs@FDA Search by Drug Name or Active Ingredient
    Where items are composed of more than one word, licence_US requires an underscore '_' in place of any spaces; e.g. Acyclovir_Sodium.

More patient friendly than the FDA's pages is Daily Med which reproduces the same details. The DailyMedID parameter, where specified, is shown in preference to the licence_US direct FDA link. Daily Med entries may be located at Search By Drug Name, e.g. for Furosemide

| DailyMedID = 3940

Pharmacokinetic data and routes of administration

In general, these parameters are relevant ro a drug. Use wikilinks for values that the general reader might not understand (e. g. hepatic, CYP3A4, intraperitoneal).

  | bioavailability   = 
  | protein_bound     = 
  | metabolism        = 
  | metabolites       =
  | onset             = 
  | elimination_half-life = 
  | duration_of_action= 
  | excretion         = 
  | routes_of_administration =

Names and identifiers

Names and identifiers in
parameter label demo order group note
Amoxicillin top title Infobox title
drug_name = N,N-Dimethyltryptamine top title demo:1; overwrites
(type=vacc,mab,comb,other) 01 type See
IUPAC_name = Systematic (IUPAC) name
MedlinePlus = MedlinePlus 25 clinical
licence_EU =
DailyMedID =
licence_US =
Licence data EMA:

US Daily Med:

26 clinical EU: demo:5; uses (alt link: [1])

US: demo:6, demo:7; DailyMedID overwrites licence_US.

Identifiers 50 id
CAS_number =
CAS_supplemental =
CAS Registry Number 78628-80-5 51 id demo:4
ATC_prefix = ATC_suffix =
ATC_supplement = ATCvet =
ATC code or
ATCvet code
J01 QG51 52 class Multi-input, interaction. Numbers have split wl+el!
PubChem = or
PubChemSubstance = (SID)
PubChem CID:  53 id Only one is shown
IUPHAR_ligand = IUPHAR/BPS 54 id demo:2
DrugBank = DrugBank 55 id
ChemSpiderID = ChemSpider 56 id +Option '=NA'
UNII = UNII 57 id
KEGG = KEGG 58 id
ChEBI = ChEBI 59 id
ChEMBL = ChEMBL 61 id
NIAID_ChemDB = NIAID ChemDB 62 id demo:3; HIV/AIDS related
synonyms = Synonyms 2-acetoxybenzoic acid
acetylsalicylate etc.
63 id demo:2; Plain, list
PDB_ligand = PDB ligand ID AIN (, ) 64 id demo:2
Notes: Demo data is taken from: default=Amoxicillin, demo:1=N,N-Dimethyltryptamine, demo:2=Aspirin, demo:3=Enfuvirtide (NIAID, HIV), demo:4=Terbinafine (CAS), demo:5= Thioridazine (licence EU), demo:6 (DailyMedID), demo:7=Thioridazine (licence US)

The DrugBank primary accession number (consisting of a 2 letter prefix (DB) and a 5 number suffix). Secondary accession numbers with a 4 letter suffix (APRD, EXPT, BIOD, NUTR) should not normally be used.


When available, the PubChem compound identifier (CID) should be used because it is unique for each chemical compound:

| PubChem        = 4091  

Make sure you choose the right CID: Often PubChem compound entries differ only very slightly, for example by an additional hydratation water or by a carbon atom with unspecified stereochemistry.

If no CID is available, which is usually the case when there is no structural information on PubChem, you may use one of the substance identifiers (SIDs):

| PubChemSubstance    = 10099  

The box won't display both CID and SID to avoid list cruft.

ATC, ATCvet and CAS

Where the drug is not included in ATC coding system (as opposed to its value just not been entered into the template) then set ATC_prefix to 'none', and the article is automatically added to Category:Drugs not assigned an ATC code rather than Category:Drugboxes with an unspecified ATC code:

| ATC_prefix        = none

Additional ATC or CAS codes may be included with the optional ATC_supplemental & CAS_supplement parameter as a comma-separated lists. CAS or ATC templates may be used to have these additional codes link to the relevant databases:

| CAS_supplemental = (acetate)
| ATC_supplemental =,   

Adds the following linked codes:

For CAS - 427-51-0 (acetate)
For ATC - M02, S01

Veterinary drugs are placed in a slightly different classification system, ATCvet. The code may be specified as ATCvet by setting the parameter ATCvet to 'yes'. Do not include the leading 'Q' in ATC_prefix:

| ATCvet            = yes 
| ATC_prefix        = N05
| ATC_suffix        = AX90
Verification and |CAS_number_Ref= like parameters

Seven identfying parameters like |CAS_number=are tracked in a . A bot adds parameters like |verifiedrevid= and |CAS_number_Ref=. See also documentation.

Chemical data

Chemical formula

You can provide the chemical formula as either the default

| chemical_formula =

or by setting atom counts for each element, in these parameters:

| C= | H= | Ag= | Al= | As= | Au= | B= | Bi= | Br= | Ca= | Cl= | Co= | F= | Fe= | Gd= | I=
| K= | Li= | Mg= | Mn= | N= | Na= | O= | P= | Pt= | S= | Sb= | Se= | Sr= | Tc= | Zn= | charge=


| C=2 | H=6 | O=1


Formula C2H6O

Irrespective of the order of assigning values to the constituent parameters, the formula is displayed with elements in the hereinbefore order. The charge parameter, if defined, is shown superscripted.


| C=2 | O=1 | H=6 | charge=+

is identical to next line

| C=2 | H=6 | O=1 | charge=+


Formula C2H6O+
Molecular weight

When the chemical formula is entered as |C=2 |O=1 |H=6, the molecular weight is calculated and presented. This value can be overwritten by using |molecular_weight=. For more informatin, see .

Other chemical data

Additional chemical data fields are SMILES and standard InChI (optionally oncluding a comment and standard InChIKey).

| SMILES            =
| StdInChI          =
| StdInChI_comment  =
| StdInChIKey       =
Physical data

This is an entirely optional section, and for most drugs is not helpful to the wider readership. Only include if information of particular interest for the drug as to its chemical propersites (e.g. in its manufacture or as an important chemical in its own right, e.g. Aspirin). If any of the following optional parameters are defined then a new section header of 'Physical data' is shown.

| density           = 
| melting_point     = 
| boiling_point     = 
| solubility        = 
| specific_rotation = 
| sec_combustion    = 

The template will add the following to the numeric values provided:

  • Density - added 'g/cm3'
  • Melting or Boiling points - added '°C' along with calculated converted value in °F.
  • Solubility - added 'mg/mL (20 °C)'


| melting_point = 100


Melting point 100 °C (212 °F)

In addition, where the melting point occurs over a range of temperatures, use melting_high for the upper value.


| melting_point = 100
| melting_high  = 104


Melting point 100–104 °C (212–219 °F)

Comments can be added to the melting and boiling point entries using melting_notes and boiling_notes.


| boiling_point = 100
| boiling_notes = (sublimes)


Boiling point 100 °C (212 °F) (sublimes)

Section overview by |type= options

In , |type= can be used to add specific sections including header:

| type=mab
| type=vaccine
| type=combo
| type=foo 

Below are all these sections in an overview. The type-condition when they show is mentioned. To be clear: in a real life article, these sections can not appear all together this way. (situation as of February 2015).

Maintenance categories

See also

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.