| Phenanthroline
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| Identifiers
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| CAS number
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66-71-7  Y
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| ChemSpider
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1278 Y
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| DrugBank
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DB02365
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| ChEBI
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CHEBI:44975 Y
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Template:Chembox ChEMBL
| RTECS number
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SF8300000
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| Jmol-3D images
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Image 1
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InChI=1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H Y
Key: DGEZNRSVGBDHLK-UHFFFAOYSA-N Y
InChI=1/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H
Key: DGEZNRSVGBDHLK-UHFFFAOYAW
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| Properties
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| Molecular formula
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C12H8N2
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| Molar mass
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180.21 g/mol
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| Appearance
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colourless crystals
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| Density
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1.31 g/cm3
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| Melting point
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117 °C, 390 K, 243 °F
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| Solubility in water
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moderate
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| Solubility in other solvents
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acetone
ethanol
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| Hazards
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| R-phrases
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R25, R50/53
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| S-phrases
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S45,S60,S61
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| Main hazards
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mild neurotoxin, strong nephrotoxin, and powerful diuretic
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| Related compounds
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| Related compounds
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2,2'-bipyridine
ferroin
phenanthrene
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 Y (verify) (what is:  Y/ N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
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| Infobox references
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Phenanthroline (phen) is a heterocyclic organic compound. It is a white solid that is soluble in organic solvents. It is used as a ligand in coordination chemistry, it forms strong complexes with most metal ions.[1] In terms of its coordination properties, phen is similar to 2,2'-bipyridine (bipy).
Synthesis
Phenanthroline may be prepared by two successive Skraup reactions of glycerol with o-phenylenediamine, catalyzed by sulfuric acid, and an oxidizing agent, traditionally aqueous arsenic acid or nitrobenzene.[2] Dehydration of glycerol gives acrolein which condenses with the amine followed by a cyclization.
Peptidase inhibitor
1,10-Phenanthroline is an inhibitor of metallopeptidases, with one of the first observed instances reported in carboxypeptidase A.[3] Inhibition of the enzyme occurs by removal and chelation of the metal ion required for catalytic activity, leaving an inactive apoenzyme. 1,10-Phenanthroline targets mainly zinc metallopeptidases, with a much lower affinity for calcium.[4]
Ferroin and analogues
The complex [Fe(phen)3]2+, called "ferroin," is used for the photometric determination of Fe(II).[5] It is used as a redox indicator with standard potential +1.06 V. The reduced ferrous form has a deep red colour and the oxidised form is light-blue.[6] Ferroin is used as a cell permeable inhibitor for metalloproteases in cell biology.
The pink complex [Ni(phen)3]2+ has been resolved into its Δ and Λ isomers.[7] The analogous [Ru(phen)3]2+ has long been known to be bioactive.[8]
Related phen ligands
A variety of substituted derivatives of phen have been examined as ligands. Neocuproine, 2,9-dimethyl-1,10-phenanthroline, is a bulky ligand. In "bathophenanthroline," the 4 and 7 positions are substituted by phenyl groups. The more electron-rich phenanthroline ligand is 3,4,7,8-tetramethyl-1,10-phenanthroline.[1]
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As an indicator for alkyllithium reagents
Alkyllithium reagents form deeply colored derivatives with phenanthroline. The alkyllithium content of solutions can be determined by treatment of such reagents with small amounts of phenanthroline (ca. 1 mg) followed by titration with alcohols to a colourless endpoint.[9]
Grignard reagents may be similarly titrated.[10]
References
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