World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0031096998
Reproduction Date:

Title: 3-Benzhydrylmorpholine  
Author: World Heritage Encyclopedia
Language: English
Subject: Desoxypipradrol, Isoethcathinone, TC-2216, ABT-202, TC-1698
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS number  YesY
ATC code ?
Chemical data
Formula C17H19NO 
Mol. mass 253.338 g/mol

3-Benzhydrylmorpholine was developed by American Home Products Corporation in the 1950s,[1] and is a drug with stimulant and anorectic effects, related to both pipradrol and phenmetrazine.


It is made from Diphenylalanine starting material.

Preparation of 3-Benzhydrylmorpholine

1. Ethyl ester.
2. LAH reduction to 1° alcohol.
3. React 3,3-diphenyl-2-amino-l-propanol with chloroacetyl chloride to yield 3,3-diphenyl-2-(α-chloro acetylamino)-1-propanol.
4. Cyclize to lactam with KOH to get 5-benzhydryl-3-morpholone.
5. LAH reduction to final product 3-benzhydrylmorpholine.

See also


  1. ^ U.S. Patent 2,993,895

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.