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Title: 4-Fluoromethylphenidate  
Author: World Heritage Encyclopedia
Language: English
Subject: HDMP-28, Carboxylate esters, Piperidines, Stimulants, Designer drugs
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate
CAS Registry Number
PubChem CID:
ChemSpider  Y
Chemical data
Formula C14H18FNO2
Molecular mass 251.3 g/mol

4-Fluoromethylphenidate (also known as 4-FMPH and 4F-MPH) is a stimulant drug that acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.[1][2][3][4][5]

Legal Status

4-Fluromethylphenidate is a Schedule I controlled substance in the US state Alabama.[6]

See also


  1. ^ Howard M. Deutsch, Qing Shi, Ewa Gruszecka-Kowalik, Margaret M. Schweri (March 1996). "Synthesis and Pharmacology of Potential Cocaine Antagonists. 2. Structure−Activity Relationship Studies of Aromatic Ring-Substituted Methylphenidate Analogs". Journal of Medicinal Chemistry 39 (6): 1201–1209.  
  2. ^ M. M. Schweri, H. M. Deutsch, A.T. Massey, S. G. Holtzman (May 2002). "Biochemical and Behavioral Characterization of Novel Methylphenidate Analogs". The Journal of Pharmacology and Experimental Therapeutics 301 (2): 527–535.  
  3. ^ Huw M.L. Davies, Darrin W. Hopper, Tore Hansen, Quixu Liu, Steven R. Childers (April 2004). "Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites". Bioorganic & Medicinal Chemistry Letters 14 (7): 1799–1802.  
  4. ^ Milind Misra, Qing Shi, Xiaocong Ye, Ewa Gruszecka-Kowalik, Wei Bu, Zhanzhu Liu, Margaret M. Schweri, Howard M. Deutsch, Carol A. Venanzi (October 2010). "Quantitative structure–activity relationship studies of threo-methylphenidate analogs". Bioorganic & Medicinal Chemistry 18 (20): 7221–7238.  
  5. ^ Satendra Singh (February 2000). "Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists". Chemical Reviews 100 (3): 925–1024.  
  6. ^ "Alabama Senate Bill 333 - Controlled substances, Schedule I, additional synthetic controlled substances and analogue substances included in, trafficking in controlled substance analogues, requisite weight increased, Secs. 13A-12-231, 20-2-23 am'd.". March 2014. Retrieved 28 September 2015. 
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