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4-hydroxy-4-methyl-2-oxoglutarate Aldolase

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Title: 4-hydroxy-4-methyl-2-oxoglutarate Aldolase  
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Subject: List of EC numbers (EC 4)
Publisher: World Heritage Encyclopedia

4-hydroxy-4-methyl-2-oxoglutarate Aldolase

4-hydroxy-4-methyl-2-oxoglutarate aldolase
EC number CAS number IntEnz BRENDA ExPASy KEGG MetaCyc metabolic pathway
PRIAM PDB structures PDBsum
Gene Ontology EGO

In chemical reaction

4-hydroxy-4-methyl-2-oxoglutarate \rightleftharpoons 2 pyruvate

Hence, this enzyme has one substrate, 4-hydroxy-4-methyl-2-oxoglutarate, and one product, pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming). Other names in common use include pyruvate aldolase, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, 4-hydroxy-4-methyl-2-ketoglutarate aldolase, and 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase. This enzyme participates in benzoate degradation via hydroxylation and c5-branched dibasic acid metabolism.


  • Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 281-302.
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