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Title: 5,7-Dihydroxytryptamine  
Author: World Heritage Encyclopedia
Language: English
Subject: DSP-4, Para-Chloroamphetamine
Publisher: World Heritage Encyclopedia


CAS number 31363-74-3
PubChem 35781
ChemSpider 32913 YesY
Jmol-3D images Image 1
Molecular formula C10H12N2O2
Molar mass 192.214
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin[1][2] used in scientific research to decrease concentrations of serotonin in the brain. The mechanism behind this effect isn't well-understood, but many believe (without clear substantiation) that it selectively kills serotonergic neurons, in a similar way that 6-hydroxydopamine (6-OHDA) is used to kill dopaminergic cells. What is known is that this compound is in fact not selective in depleting serotonin content, but also depletes norepinephrine. To selectively deplete serotonin stores, it is commonly administered in conjunction with desmethylimiprimine (desipramine), which inhibits the norepinephrine transporter.

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