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Title: 5f-ab-pinaca  
Author: World Heritage Encyclopedia
Language: English
Subject: Cannabinoids, 5F-ADB, 5F-EMB-PINACA, AB-CHFUPYCA, PX-3
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS Registry Number
Chemical data
Formula C18H25FN4O2
Molecular mass 348.4 g/mol

5F-AB-PINACA is an indazole-based synthetic cannabinoid that is derived from a series of compounds originally developed by Pfizer in 2009 as an analgesic medication, and has been sold online as a designer drug.[1][2]

5F-AB-PINACA has been reported to be a potent agonist of the CB1 receptor and CB2 receptor with EC50 values of 0.48 nM and 2.6 nM respectively.[3] Its metabolism has been described in literature.[4][5]


  • Legality 1
    • China 1.1
    • Germany 1.2
    • Singapore 1.3
  • See also 2
  • References 3



As of October 2015 5F-AB-PINACA is a controlled substance in China.[6]


5F-AB-PINACA is listed in Anlage II and therefore illegal in Germany as of May 2015.[7]


It is also listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.[8]

See also


  1. ^ "Patent WO/2009/106980 - Indazole derivatives". 
  2. ^ "5F-AB-PINACA". Cayman Chemical. Retrieved 5 July 2015. 
  3. ^ Samuel D Banister, Michael Moir, Jordyn Stuart, Richard C Kevin, Katie E Wood, Mitchell Longworth, Shane M Wilkinson, Corinne Beinat, Alxendra S Buchanan, Michelle Glass, Mark Connor, Iain S McGregor, Michael Kassiou (July 2015). "The pharmacology of indole and indazole synthetic cannabinoid designer drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA and 5F-ADBICA". ACS Chemical Neuroscience.  
  4. ^ Ariane Wohlfarth, Marisol S. Castaneto, Mingshe Zhu, Shaokun Pang, Karl B. Scheidweiler, Robert Kronstrand, Marilyn A. Huestis (May 2015). "Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA". The AAPS Journal 17 (3): 660–677.  
  5. ^ Moonhee Jang, Ilchung Shin, Jihyun Kim, Wonkyung Yang (February 2015). "Simultaneous quantification of 37 synthetic cannabinoid metabolites in human urine by liquid chromatography-tandem mass spectrometry". Forensic Toxicology.  
  6. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015. 
  7. ^ "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)". Retrieved 5 July 2015. 
  8. ^ "CNB NEWS RELEASE". Central Narcotics Bureau (CNB). 30 April 2015. Retrieved 24 July 2015. 

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