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6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide

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Title: 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide  
Author: World Heritage Encyclopedia
Language: English
Subject: SB-242084, 5-HT2C receptor, RS-56812, BRL-54443, MPPF
Collection: 5-Ht2C Antagonists
Publisher: World Heritage Encyclopedia
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6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide

6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
Systematic (IUPAC) name
6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
Clinical data
Legal status
?
Identifiers
ATC code ?
Chemical data
Formula C16H16ClN3O2 
Mol. mass 317.769 g/mol

6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide (CEPC) is a drug which acts as a potent and selective antagonist for the serotonin 5-HT2C receptor. In animal studies it was found to potentiate the conditioned place preference induced by low-dose amphetamine, demonstrating that 5-HT2C-mediated disinhibition of dopamine release can cause interactions with dopaminergic drugs.[1]

See also

References

  1. ^ McCorvy JD, Harland AA, Maglathlin R, Nichols DE. A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference. Neuroscience Letters. 2011 Nov 7;505(1):10-3. PMID 21827831
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