World Library  
Flag as Inappropriate
Email this Article

7-Chlorokynurenic acid

Article Id: WHEBN0041066963
Reproduction Date:

Title: 7-Chlorokynurenic acid  
Author: World Heritage Encyclopedia
Language: English
Subject: NMDA receptor antagonist, NMDA receptor antagonists, A.C.E. mixture, MMPIP, LY-344,545
Collection: Antidepressants, Aromatic Acids, Chloroarenes, Excitatory Amino Acid Reuptake Inhibitors, Nmda Receptor Antagonists, Quinolones
Publisher: World Heritage Encyclopedia

7-Chlorokynurenic acid

7-Chlorokynurenic acid
Systematic (IUPAC) name
7-chloro-4-oxo-1H-quinoline-2-carboxylic acid
CAS Registry Number
ATC code None
PubChem CID:
Synonyms 7-chlorokynurenate; 7-CTKA
Chemical data
Formula C10H6ClNO3
Molecular mass 223.61254 g/mol

7-Chlorokynurenic acid (7-CKA) is a drug that acts as a potent and selective noncompetitive antagonist of the glycine site of the NMDA receptor.[1] It produces ketamine-like rapid antidepressant effects in animal models of depression.[2] However, 7-CKA is unable to cross the blood-brain-barrier, and for this reason, is unsuitable for clinical use.[3] As a result, a centrally-penetrant prodrug of 7-CKA, 4-chlorokynurenine (AV-101), has been developed for use in humans, and is being studied in clinical trials as a potential treatment for major depressive disorder.[3][4] In addition to antagonizing the NMDA receptor, 7-CKA also acts as a potent inhibitor of the reuptake of glutamate into synaptic vesicles (or as a vesicular glutamate reuptake inhibitor), an action that it mediates via competitive blockade of vesicular glutamate transporters (Ki = 0.59 mM).[5]

See also


  1. ^
  2. ^
  3. ^ a b
  4. ^
  5. ^

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.