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Alpha-Pyrrolidinohexiophenone

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Title: Alpha-Pyrrolidinohexiophenone  
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Subject: 3',4'-Dimethoxy-α-pyrrolidinopentiophenone, 4'-Methyl-α-pyrrolidinohexiophenone, Alpha-Pyrrolidinobutiophenone, Alpha-Pyrrolidinopropiophenone, Alpha-Pyrrolidinopentiophenone
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Alpha-Pyrrolidinohexiophenone

alpha-Pyrrolidinohexiophenone
Systematic (IUPAC) name
(±)-1-Phenyl-2-(1-pyrrolidinyl)-1-hexanone
Clinical data
Legal status
  • UK: Class B
  • Illegal in China and Sweden
Routes of
administration
oral, intranasal, vaporization, intravenous, rectal, sublingual,subcutaneous
Identifiers
CAS Registry Number  Y
Chemical data
Formula C16H23NO
Molecular mass 245.37 g·mol−1

α-Pyrrolidinohexiophenone (α-PHP, alpha-PHP, α-Pyrrolidinohexanophenone, PV-7) is a synthetic stimulant drug of the cathinone class developed in the 1960s[1] which has been reported as a novel designer drug.[2][3][4][5] It is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain, and is a structural isomer of pyrovalerone.[6]

Legality

Sweden's public health agency suggested to classify α-PHP as narcotic on June 1, 2015.[7]

As of October 2015 α-PHP is a controlled substance in China.[8]

See also

References

  1. ^ "US Patent 3314970 - α-Pyrrolidino ketones". Ernst Seeger. Retrieved 18 June 2015. 
  2. ^ Nahoko Uchiyama, Yoshihiko Shimokawa, Maiko Kawamura, Ruri Kikura-Hanajiri, Takashi Hakamatsuka (August 2014). "Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products". Forensic Toxicology 32 (2): 266–281.  
  3. ^ Milena Majchrzak, Marcin Rojkiewicz, Rafał Celiński, Piotr Kuś, Mieczysław Sajewicz (October 2015). "Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials". Forensic Toxicology.  
  4. ^ Michael Paul, Sergej Bleicher, Susanne Guber, Josef Ippisch, Aldo Polettini, Wolfgang Schultis (November 2015). "Identification of phase I and II metabolites of the new designer drug α-pyrrolidinohexiophenone (α-PHP) in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)". Journal of Mass Spectrometry 50 (11): 1305–1317.  
  5. ^ "α-Pyrrolidinohexanophenone". Cayman Chemical. Retrieved 17 June 2015. 
  6. ^ Meltzer PC, Butler D, Deschamps JR, Madras BK. (February 2006). "1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogs. A promising class of monoamine uptake inhibitors". Journal of Medicinal Chemistry 49 (4): 1420–1432.  
  7. ^ "23 nya ämnen kan klassas som narkotika eller hälsofarlig vara". Retrieved 29 June 2015. 
  8. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015. 
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