World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0000613933
Reproduction Date:

Title: Anorectic  
Author: World Heritage Encyclopedia
Language: English
Subject: Stimulant, Aminorex, Cigarette smoking for weight loss, Formetorex, P57 (glycoside)
Collection: Anorectics
Publisher: World Heritage Encyclopedia


An anorectic or anorexic (from the Greek an- = "without" and orexis = "appetite"), also known as anorexigenic, anorexiant, or appetite suppressant, is a dietary supplement and/or drug which reduces appetite, resulting in lower food consumption, leading to weight loss.[1] By contrast, an appetite stimulant is referred to as orexigenic.


  • List of centrally acting anorectics 1
  • List of peripherally acting anorectics 2
  • Public health concerns 3
    • Non-pharmacological alternatives 3.1
  • History 4
  • References 5
  • External links 6

List of centrally acting anorectics

Numerous pharmaceutical compounds are marketed as appetite suppressants.

The following drugs listed as "centrally-acting antiobesity preparations" in the Anatomical Therapeutic Chemical Classification System:[2]

The following are listed as appetite depressants by MeSH, an index of medical journal articles and books.[3]

Other compounds with known appetite suppressant activity include:

Where † indicates drugs that have been since withdrawn from the market because of adverse effects.

List of peripherally acting anorectics

There is only one member in group—orlistat (Xenical).

Public health concerns

Epidemics of fatal pulmonary hypertension and heart valve damage associated with pharmaceutical anorectic agents have led to the withdrawal of products from the market. This was the case with aminorex in the 1960s, and again in the 1990s with fenfluramine (see: Fen-phen).[4] Likewise, association of the related appetite suppressant phenylpropanolamine with hemorrhagic stroke led the Food and Drug Administration (FDA) to request its withdrawal from the market in the United States in 2000, and similar concerns regarding ephedrine resulted in an FDA ban on its inclusion in dietary supplements, in 2004 (a Federal judge later overturned this ban in 2005 during a challenge by supplement maker Nutraceuticals). It is also debatable as to whether the ephedrine ban had more to do with its use as a precursor in methamphetamine manufacture rather than legitimate health concerns.

Non-pharmacological alternatives

  • Weight loss effects of water have been subject to some scientific research.[5] Drinking water prior to each meal may help in appetite suppression. Consumption of 500 mL (approximately 17 fl oz) of water 30 minutes before meals has been correlated with modest weight loss (1–2 kg) in obese men[6] and women.[7]


Used on a short-term basis clinically to treat obesity, some appetite suppressants are also available over-the-counter. Most common natural appetite suppressants are based on Hoodia, a genus of 13 species in the flowering plant family Apocynaceae, under the subfamily Asclepiadoideae. Several appetite suppressants are based on a mix of natural ingredients, mostly using green tea as its basis, in combination with other plant extracts such as fucoxanthin, found naturally in seaweed. Drugs of this class are frequently stimulants of the phenethylamine family, related to amphetamine (informally known as speed).

The German and Finnish[8] militaries issued amphetamines to soldiers commonly to enhance warfare during the Second World War.[9] Following the war, amphetamines were redirected for use on the civilian market. Indeed, amphetamine itself was sold commercially as an appetite suppressant until it was outlawed in most parts of the world in the late 1950s because of safety issues. Many amphetamines produce side effects, including addiction, tachycardia and hypertension,[10] making prolonged unsupervised use dangerous.


  1. ^ Lemke, Thomas L.; Williams, David A. (2012). "Anorexiants as Pharmacologic Agents in the Management of Obesity". Foye's Medicinal Chemistry. 
  2. ^ ATC/DDD Index
  3. ^ MeSH list of agents 82001067
  4. ^ Fishman AP. Aminorex to Fen/Phen: An Epidemic Foretold. Circulation 1999;99:156. Fulltext. PMID 9884392
  5. ^ "Pre-meal water consumption for weight loss". Australian Family Physician 42 (7): 478. 2013. 
  6. ^ Dennis EA, Dengo AL, Comber DL, Flack KD, Savla J, Davy KP, Davy BM. "Water consumption increases weight loss during a hypocaloric diet intervention in middle-aged and older adults." Obesity (Silver Spring) 2010 Feb;18(2):300-7. [1] doi: 10.1038/oby.2009.235. PMID 19661958
  7. ^ Vij VA, Joshi AS. "Effect of excessive water intake on body weight, body mass index, body fat, and appetite of overweight female participants." J Nat Sci Biol Med. 2014 Jul;5(2):340-4. [2]. doi:10.4103/0976-9668.136180 PMID 25097411
  8. ^ Pervitiini
  9. ^ Andreas Ulrich, Andreas. "The Nazi Death Machine: Hitler's Drugged Soldiers - SPIEGEL ONLINE - News - International". Spiegel Online. Retrieved 2011-01-05. 
  10. ^ Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X, Higenbottam T, Oakley C, Wouters E, Aubier M, Simonneau G, Begaud B. Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension. N Engl J Med 1996;335:609. Fulltext. doi:10.1056/NEJM199608293350901 PMID 8692238

External links

  • Questions and Answers about appetite suppressant medication treatment from the Medical College of Wisconsin
  • Anorectics at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Mitchell, Kari (January 1997). "Anorexiant Agents: Considerations for Use" (PDF). Drug Therapy Topics.  
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.