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Title: Benperidol  
Author: World Heritage Encyclopedia
Language: English
Subject: Butyrophenone, Antipsychotic, Janssen Pharmaceutica, Butaclamol, Spiramide
Collection: Belgian Inventions, Benzimidazoles, Butyrophenone Antipsychotics, Janssen Pharmaceutica, Organofluorides, Piperidines
Publisher: World Heritage Encyclopedia


Skeletal formula of benperidol
Ball-and-stick model of the benperidol molecule
Systematic (IUPAC) name
Clinical data
Legal status
Routes of
CAS Registry Number  N
ATC code N05
PubChem CID:
ChemSpider  Y
Chemical data
Formula C22H24FN3O2
Molecular mass 381.443 g/mol

Benperidol is a drug which is a highly potent butyrophenone derivative. It is the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).[1] It is an antipsychotic, which can be used for the treatment of schizophrenia,[2] but it is primarily used to control antisocial hypersexual behaviour,[3] and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone acetate.[4]

Benperidol was discovered at Janssen Pharmaceutica in 1961.


  1. ^ Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)
  2. ^ Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.
  3. ^ British National Formulary (49th), British Medical Association 2005 p 183
  4. ^ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.
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