World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0012434982
Reproduction Date:

Title: Brivaracetam  
Author: World Heritage Encyclopedia
Language: English
Subject: Seletracetam, Racetams, Racetam, Nootropics, SIB-1553A
Collection: Amides, Anticonvulsants, Pyrrolidones, Racetams
Publisher: World Heritage Encyclopedia


ChemSpider  YesY
Jmol-3D images Image 1
Molecular formula C11H20N2O2
Molar mass 212.29 g mol−1
Routes of
Legal status


Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

Brivaracetam, the 4-n-propyl analog of levetiracetam, is a racetam derivative with anticonvulsant properties.[1][2] Brivaracetam is believed to act by binding to the ubiquitous synaptic vesicle protein SV2.[3] Phase II clinical trials in adult patients with refractory partial seizures were promising. Positive preliminary results from stage III trials have been recorded,[4][5] along with evidence that it is around 10 times more potent[6] for the prevention of certain types of seizure in mouse models than levetiracetam, of which it is an analogue.


  1. ^ von Rosenstiel P (2007). "Brivaracetam (UCB 34714)". Neurotherapeutics 4 (1): 84–7.  
  2. ^ Malawska B, Kulig K (2005). "Brivaracetam UCB". Curr Opin Investig Drugs 6 (7): 740–746.  
  3. ^ Rogawski MA, Bazil CW (2008). "New molecular targets for antiepileptic drugs: α2δ, SV2A, and K(v)7/KCNQ/M potassium channels". Curr Neurol Neurosci Rep 8 (4): 345–352.  
  4. ^
  5. ^ Rogawski M (2008). "Brivaracetam: a rational drug discovery success story". Br J Pharmacol 154 (8): 1555–7.  
  6. ^

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.