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Brivaracetam

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Title: Brivaracetam  
Author: World Heritage Encyclopedia
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Subject: Seletracetam, Racetams, Racetam, Nootropics, SIB-1553A
Collection: Amides, Anticonvulsants, Pyrrolidones, Racetams
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Brivaracetam

Brivaracetam
Identifiers
PubChem
ChemSpider  YesY
ChEMBL
Jmol-3D images Image 1
Properties
Molecular formula C11H20N2O2
Molar mass 212.29 g mol−1
Pharmacology
Routes of
administration
Oral
Legal status


?(US)

Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

Brivaracetam, the 4-n-propyl analog of levetiracetam, is a racetam derivative with anticonvulsant properties.[1][2] Brivaracetam is believed to act by binding to the ubiquitous synaptic vesicle protein SV2.[3] Phase II clinical trials in adult patients with refractory partial seizures were promising. Positive preliminary results from stage III trials have been recorded,[4][5] along with evidence that it is around 10 times more potent[6] for the prevention of certain types of seizure in mouse models than levetiracetam, of which it is an analogue.

References

  1. ^ von Rosenstiel P (2007). "Brivaracetam (UCB 34714)". Neurotherapeutics 4 (1): 84–7.  
  2. ^ Malawska B, Kulig K (2005). "Brivaracetam UCB". Curr Opin Investig Drugs 6 (7): 740–746.  
  3. ^ Rogawski MA, Bazil CW (2008). "New molecular targets for antiepileptic drugs: α2δ, SV2A, and K(v)7/KCNQ/M potassium channels". Curr Neurol Neurosci Rep 8 (4): 345–352.  
  4. ^ http://www.clinicaltrials.gov/ct2/show/NCT00464269?term=brivaracetam&rank=5
  5. ^ Rogawski M (2008). "Brivaracetam: a rational drug discovery success story". Br J Pharmacol 154 (8): 1555–7.  
  6. ^ http://onlinelibrary.wiley.com/doi/10.1038/bjp.2008.198/full


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