Cd41

Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
PDB rendering based on 1txv.
Available structures
PDB Ortholog search: RCSB
Identifiers
ITGA2B Gene
RNA expression pattern

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene.

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[1]

Interactions

ITGA2B has been shown to interact with AUP1[2] and CLNS1A.[3]

See also

References

Further reading

External links

  • Medical Subject Headings (MeSH)
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