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Cdc42

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Title: Cdc42  
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Subject: List of MeSH codes (D12.776.476), Epithelial polarity, Filopodia, BCR (gene), Competing endogenous RNA (CeRNA)
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Cdc42

Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.[1][2]

Contents

  • Function 1
  • Interactions 2
  • References 3
  • Further reading 4
  • External links 5

Function

Human CDC42 is a small GTPase of the Rho family, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.[3]

Interactions

CDC42 has been shown to interact with:

References

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Further reading

External links

  • cdc42 GTP-Binding Protein at the US National Library of Medicine Medical Subject Headings (MeSH)
  • CDC42 Info with links in the Cell Migration Gateway



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