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Cdppb

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Cdppb

CDPPB
Systematic (IUPAC) name
3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
PubChem
IUPHAR ligand
ChemSpider
Chemical data
Formula C23H18N4O 
Mol. mass 366.414 g/mol
 YesY   

CDPPB is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.[1][2][3] It has antipsychotic effects in animal models,[4] and mGluR5 modulators are under investigation as potential drugs for the treatment of schizophrenia,[5] as well as other applications.[6][7]

References

  1. ^ Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR (November 2004). "Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo". Journal of Medicinal Chemistry 47 (24): 5825–8.  
  2. ^ de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, Baldwin RM, Tamagnan GD, Conn PJ (June 2006). "Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes". Journal of Medicinal Chemistry 49 (11): 3332–44.  
  3. ^ Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ (May 2007). "Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses". Molecular Pharmacology 71 (5): 1389–98.  
  4. ^ Kinney GG, O'Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK, Chen TB, Wisnoski DD, Lindsley CW, Tiller PR, Smith S, Jacobson MA, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL (April 2005). "A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models". The Journal of Pharmacology and Experimental Therapeutics 313 (1): 199–206.  
  5. ^ Lindsley CW, Shipe WD, Wolkenberg SE, Theberge CR, Williams DL, Sur C, Kinney GG (2006). "Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia". Current Topics in Medicinal Chemistry 6 (8): 771–85.  
  6. ^ Lecourtier L, Homayoun H, Tamagnan G, Moghaddam B (October 2007). "Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex". Biological Psychiatry 62 (7): 739–46.  
  7. ^ Gass JT, Olive MF (April 2009). "Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory". Biological Psychiatry 65 (8): 717–20.  


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