World Library  
Flag as Inappropriate
Email this Article

Cannabinol

Article Id: WHEBN0001231976
Reproduction Date:

Title: Cannabinol  
Author: World Heritage Encyclopedia
Language: English
Subject: Tetrahydrocannabinol, Cannabis (drug), Cannabinoid, CP 55,940, Nabitan
Collection: Benzochromenes, Cannabinoids, Cb1 Receptor Agonists, Cb2 Receptor Agonists, Natural Phenols
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Cannabinol

Cannabinol
Systematic (IUPAC) name
6,6,9-Trimethyl-3-pentyl-benzo[c]chromen-1-ol
Identifiers
CAS Registry Number  N
ATC code None
PubChem CID:
IUPHAR/BPS
ChemSpider  Y
UNII  Y
KEGG  Y
ChEMBL  Y
Chemical data
Formula C21H26O2
Molecular mass 310.4319 g/mol
Physical data
Melting point 77 °C (171 °F) [1]
Solubility in water

insoluble in water[2]

soluble in methanol[3] and ethanol[4] mg/mL (20 °C)
 N   

Cannabinol (CBN) is a weak psychoactive cannabinoid found only in trace amounts in Cannabis sativa and Cannabis indica.[5] It is mostly a metabolite of tetrahydrocannabinol (THC).[6] CBN acts as a weak agonist of CB1 receptors, but has a higher affinity to CB2 receptors, with lower affinities in comparison to THC.[7][8] Cannabinol has been shown to have analgesic properties.[9]

As happens with many other cannabinoids, CBN stems from CBGA. Naturally, cannabis plants produce enzymes that convert CBGA to different cannabinoids such as CBCA, CBDA or THCA. If a sample is exposed to air for a prolongued period of time, THCA will convert to CBNA. CBN is then formed by decarboxylation of CBNA.[10]

Contents

  • Chemistry 1
  • Legal status 2
    • United States 2.1
  • See also 3
  • References 4
  • External links 5

Chemistry

In contrast to THC, CBN has no double bond isomers nor stereoisomers.

Legal status

CBN is not scheduled by the United Nations' Convention on Psychotropic Substances.

United States

CBN is not scheduled at the federal level in the United States,[11] but it could legally be considered an analog of THC and sales or possession could be prosecuted under the Federal Analogue Act.

Cannabinol 10 mg transdermal patches
Cannabinol 10 mg transdermal patches sold at dispensaries in Colorado, USA

See also

References

  1. ^ Cannabinol in the ChemIDplus database.
  2. ^ David R. Lide (2012). CRC Handbook of Chemistry and Physics. CRC Press. pp. 3–90.  
  3. ^ Sigma-Aldrich Co., Cannabinol solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis.
  4. ^ Biotrend: Cannabinol (PDF: 21 kB)
  5. ^ Karniol IG, Shirakawa I, Takahashi RN, Knobel E, Musty RE (1975). "Effects of delta9-tetrahydrocannabinol and cannabinol in man". Pharmacology 13 (6): 502–12.  
  6. ^ McCallum ND, Yagen B, Levy S, Mechoulam R (May 1975). "Cannabinol: a rapidly formed metabolite of delta-1- and delta-6-tetrahydrocannabinol". Experientia 31 (5): 520–1.  
  7. ^ Mahadevan A, Siegel C, Martin BR, Abood ME, Beletskaya I, Razdan RK (October 2000). "Novel cannabinol probes for CB1 and CB2 cannabinoid receptors". Journal of Medicinal Chemistry 43 (20): 3778–85.  
  8. ^ Petitet F, Jeantaud B, Reibaud M, Imperato A, Dubroeucq MC (1998). "Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors". Life Sciences 63 (1): PL1–6.  
  9. ^ http://link.springer.com/article/10.1007%2FBF00421466
  10. ^ Medical Jane, Cannabinol CBN
  11. ^ §1308.11 Schedule I.

External links

  • Erowid Compounds found in Cannabis sativa
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.