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Cyclin-dependent kinase 10

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Title: Cyclin-dependent kinase 10  
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Subject: ETS2, Postreplication checkpoint, Cellular apoptosis susceptibility protein, Cyclin B2, CDKN2D
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Cyclin-dependent kinase 10


Cyclin-dependent kinase 10
Identifiers
Symbols  ; PISSLRE
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.[1][2][3] The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.[3]

Interactions

Cyclin-dependent kinase 10 has been shown to interact with ETS2.[4]

References

  1. ^ Grana X, Claudio PP, De Luca A, Sang N, Giordano A (Jul 1994). "PISSLRE, a human novel CDC2-related protein kinase". Oncogene 9 (7): 2097–103.  
  2. ^ Brambilla R, Draetta G (Oct 1994). "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene 9 (10): 3037–41.  
  3. ^ a b "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10". 
  4. ^ Kasten, M; Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene (England) 20 (15): 1832–8.  

Further reading

External links


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