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Cyprodime

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Title: Cyprodime  
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Subject: List of opioids, Samidorphan, Naloxone, Hydrocodone, Ethers
Collection: Ethers, Ketones, Morphinans, Opioid Antagonists, Phenol Ethers, Synthetic Opioids
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Cyprodime

Cyprodime
Systematic (IUPAC) name
(–)-N-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code None
PubChem
ChemSpider  N
ChEMBL  N
Synonyms Cyprodime
Chemical data
Formula C22H29NO3 
Mol. mass 355.471 g/mol
 N   

Cyprodime is an opioid antagonist from the morphinan family of drugs.

Cyprodime is a selective opioid antagonist which blocks the μ-opioid receptor,[1] but without affecting the δ-opioid or κ-opioid receptors. This makes it useful for scientific research as it allows the μ-opioid receptor to be selectively deactivated so that the actions of the δ and κ receptors can be studied separately, in contrast to better known opioid antagonists such as naloxone which block all three opioid receptor subtypes.[2]

See also

References

  1. ^ Schmidhammer H, Burkard WP, Eggstein-Aeppli L, Smith CF. Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N- (cyclopropylmethyl)- 4,14-dimethoxymorphinan- 6-one, a selective mu opioid receptor antagonist. Journal of Medicinal Chemistry. 1989 Feb;32(2):418-21. PMID 2536439
  2. ^ Márki A, Monory K, Otvös F, Tóth G, Krassnig R, Schmidhammer H, Traynor JR, Roques BP, Maldonado R, Borsodi A. Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays. European Journal of Pharmacology. 1999 Oct 27;383(2):209-14. PMID 10585536



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