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5,7-Dichlorokynurenic acid

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Title: 5,7-Dichlorokynurenic acid  
Author: World Heritage Encyclopedia
Language: English
Subject: 7-Chlorokynurenic acid, NMDA receptor antagonists, Quinolines, Carboxylic acids, Chloroarenes
Publisher: World Heritage Encyclopedia

5,7-Dichlorokynurenic acid

5,7-Dichlorokynurenic acid
IUPAC name
5,7-dichloro-4-oxo-1H-quinoline-2-carboxylic acid
ChemSpider  N
Jmol-3D images Image
Molar mass 258.05 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N  (: Y/N?)

5,7-Dichlorokynurenic acid (DCKA) is a selective NMDA receptor antagonist acting at the glycine site of the NMDA receptor complex.[1]

See also


  1. ^ McNamara D, Smith EC, Calligaro DO, O'Malley PJ, McQuaid LA, Dingledine R. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neuroscience Letters. 1990 Nov 27;120(1):17-20. PMID 2149877
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