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Title: Dcpg  
Author: World Heritage Encyclopedia
Language: English
Subject: A.C.E. mixture, LY-344,545, EGLU, LY-307,452, MMPIP
Collection: Amino Acid Derivatives, Anticonvulsants, Mglu8 Receptor Agonists, Tricarboxylic Acids
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]phthalic acid
CAS Registry Number  YesY
PubChem CID:
ChemSpider  N
Chemical data
Formula C10H9NO6
Molecular mass 239.181 g/mol

DCPG ((S)-3,4-DCPG) is a drug used in scientific research, which acts as a potent and subtype-selective agonist for the metabotropic glutamate receptor mGluR8. It has anticonvulsant effects in animal studies,[1][2] and has also been investigated as a possible treatment for hyperalgesia.[3]


  1. ^ Moldrich RX, Chapman AG, De Sarro G, Meldrum BS. Glutamate metabotropic receptors as targets for drug therapy in epilepsy. European Journal of Pharmacology. 2003 Aug 22;476(1-2):3-16. doi:10.1016/S0014-2999(03)02149-6 PMID 12969743
  2. ^ Folbergrová J, Druga R, Haugvicová R, Mares P, Otáhal J. Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid. Neuropharmacology. 2008 Mar;54(4):665-75. PMID 18191956
  3. ^ Marabese I, de Novellis V, Palazzo E, Scafuro MA, Vita D, Rossi F, Maione S. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 Feb;52(2):253-62. PMID 17113112

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