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Title: Dermatofibroma  
Author: World Heritage Encyclopedia
Language: English
Subject: List of diseases (D)
Publisher: World Heritage Encyclopedia


Classification and external resources
ICD-10 9 ICD-O: M8830/0
DiseasesDB eMedicine MeSH D018219

Benign fibrous histiocytomas (also known as "Dermal dendrocytoma,"[1] "Dermatofibroma,"[2] "Fibrous dermatofibroma,"[2] "Fibrous histiocytoma"[2]:668, "Fibroma simplex",[1] "Nodular subepidermal fibrosis",[1] and "Sclerosing hemangioma"[1]) are benign skin growths.[3]


Dermatofibromas are hard solitary slow-growing papules (rounded bumps) that may appear in a variety of colours, usually brownish to tan. In addition, they are often elevated or pedunculated. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.[4] They are composed of disordered collagen laid down by fibroblasts. Dermatofibromas are classed as benign skin lesions meaning that they are completely harmless though it may be confused with a variety of subcutaneous tumours.[5]

Dermatofibroma can be found anywhere on the body but most often they are found on the legs and arms.[6]

Deep penetrating dermatofibroma may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans.[7]

Dermatofibromas occur most often in women; the male to female ratio is about 1:4.[4] The age group in which the nodule occurs is twenty to forty-five years.

It is associated with the dimple sign; by applying lateral pressure, there is a central depression of the dermatofibroma.

Immunohistochemical staining

Neoplasm CD34[1] Stromelysin-3[8] Factor XIIIa[9]
Dermatofibroma + + +
Dermatofibrosarcoma protuberans + - -

See also


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