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Title: Desmethoxyyangonin  
Author: World Heritage Encyclopedia
Language: English
Subject: Kava, Kavalactone, C14H12O3
Publisher: World Heritage Encyclopedia


CAS number 15345-89-8 N
PubChem 5273621
ChemSpider 4438012 YesY
Jmol-3D images Image 2
Molecular formula C14H12O3
Molar mass 228.24 g mol−1
Appearance white to faint yellow powder
Density 1.18 g/mL
Melting point

148 °C, 421 K, 298 °F

Boiling point

440 °C, 713 K, 824 °F

 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Desmethoxyyangonin or 5,6-dehydrokawain is one of the six major kavalactones found in the Piper methysticum (kava) plant.


Desmethoxyyangonin is a reversible inhibitor of monoamine oxidase B (MAO-B).[1] Kava is able to increase dopamine levels in the nucleus accumbens[2] and desmethoxyyangonin likely contributes to this effect. This, along with the potential increases of serotonin and other catecholamine concentrations, may be responsible for the purported attention-promoting effects of kava.

Desmethoxyyangonin has marked activity on the induction of CYP3A23.[3]


See also

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