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Title: Ditran  
Author: World Heritage Encyclopedia
Language: English
Subject: CAR-301,060, EA-3167, EA-3443, CAR-226,086, EA-3580
Collection: Alcohols, Anticholinergics, Carboxylate Esters, Deliriants, Piperidines, Pyrrolidines
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
mixture of (1-ethylpyrrolidin-2-yl)methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate and (1-ethylpiperidin-3-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetate
Clinical data
Legal status
CAS number  YesY
ATC code ?
Chemical data
Formula C20H29NO3 
Mol. mass 331.448 g/mol

Ditran (JB-329) is an anticholinergic drug mixture, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB).

Ditran is composed of a mixture of 70% 1-ethyl-2-pyrrolidinylmethyl-alpha- phenylcyclopentylglycolate and 30% 1-ethyl-3-piperidyl-alpha-phenylcyclopentylglycolate. These compounds are structural isomers and have very similar pharmacological properties. The piperidine compound is the more potent of the two and the reason the mixture was used was because of ease of manufacture, however it is also possible to make the piperidine compound in its pure form, so there were ultimately two forms of Ditran used in research, the original 70/30 mix, and "Ditran-B", the pure piperidine compound. Ditran was developed during chemical weapons research in an attempt to produce non-lethal incapacitating agents, similar to QNB itself. The ditran mixture is more potent as an anticholinergic than the piperidyl benzilate drugs such as N-methyl-3-piperidyl benzilate, but is less potent than QNB.[1][2]

There has been a modest amount of scientific research using this mixture,[3][4] but most modern research using these kind of anticholinergic drugs uses N-methyl-3-piperidyl benzilate due to its wider availability.

See also


  1. ^ Siegfried Franke; Peter Franz; Werner Warnke (1975). Lehrbuch der Militärchemie. Bd. 1. Ost-Berlin: Militärverlag der Deutschen Demokratischen Republik. 
  2. ^ Commission on Life Sciences (1982). Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents 1. The National Academies Press. pp. 191–195. 
  3. ^ Volle, R. L.; Alkadhi, K. A.; Branisteanu, D. D.; Reynolds, L. S.; Epstein, P. M.; Smilowitz, H.; Lambert, J. J.; Henderson, E. G. (1982). "Ketamine and ditran block end-plate ion conductance and [3H]phencyclidine binding to electric organ membrane". The Journal of Pharmacology and Experimental Therapeutics 221 (3): 570–576.  
  4. ^ Vanderwolf, C. H.; Stewart, D. J. (1986). "Joint cholinergic-serotonergic control of neocortical and hippocampal electrical activity in relation to behavior: effects of scopolamine, ditran, trifluoperazine and amphetamine". Physiology & Behavior 38 (1): 57–65.  

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