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Title: Ea-3148  
Author: World Heritage Encyclopedia
Language: English
Subject: Nerve agent, Chemical warfare, VR (nerve agent), Soman, Tabun (nerve agent)
Collection: Anticholinesterases, Chemical Weapons, Nerve Agents, Phosphonothioates
Publisher: World Heritage Encyclopedia


CAS number  YesY
Jmol-3D images Image 1
Molecular formula C12H26NO2PS
Molar mass 279.378 g/mol
Density 1.05 g/mL
Boiling point 111.11 °C (232.00 °F; 384.26 K)
Main hazards Highly Toxic
NFPA 704
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

EA-3148 (Substance 100A) is a "V-series" nerve agent related to the better-known compounds VX and VR.[1] It was studied by both the US and Soviet chemical weapons programmes during the Cold War, and is notable as the only nerve agent specifically identified in public domain sources as having a higher absolute potency as an acetylcholinesterase inhibitor than VX (around 50% more potent by weight).[2] However, both the US and Soviet investigations of the compound concluded that despite its high potency, the physicochemical properties of the substance made it unsuitable for weaponisation, and further research was not conducted.[3] The chemical structure of EA-3148 falls within the scope of compounds designated "Toxic chemicals" under Schedule 1 of the Chemical Weapons Convention and so it is illegal throughout the world under international law and may only be used for certain types of scientific and medical research.


  1. ^ Ellison, D. H. (2008). Handbook of Chemical and Biological Warfare Agents (2nd ed.). p. 28.  
  2. ^ Commission on Life Sciences (1982). Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents 1. The National Academies Press. pp. 7, 22, 29, E3. 
  3. ^ Mirzayanov, V. S. (2009). State Secrets. An Insider's Chronicle of the Russian Chemical Weapons Program. pp. 127–128.  
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