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Title: Eglu  
Author: World Heritage Encyclopedia
Language: English
Subject: DNQX, DCPG, L-AP4, WAY-213,613, LY-341,495
Collection: Mglu2 Receptor Antagonists, Mglu3 Receptor Antagonists, Neuroscience
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
(2S)-2-amino-2-ethylpentanedioic acid
Clinical data
Legal status
CAS number  YesY
ATC code ?
IUPHAR ligand
Chemical data
Formula C7H13NO4 
Mol. mass 175.182 g/mol

(2S)-α-Ethylglutamic acid (EGLU) is a drug that is used in neuroscience research. It was one of the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and so has been useful in the characterisation and study of this receptor subfamily.[1][2][3][4][5][6][7]


  1. ^ Jane, DE; Thomas, NK; Tse, HW; Watkins, JC (1996). "Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord". Neuropharmacology 35 (8): 1029–35.  
  2. ^ Huang, L; Rowan, MJ; Anwyl, R (1999). "Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro". European Journal of Pharmacology 366 (2–3): 151–8.  
  3. ^ Palazzo, E; Marabese, I; De Novellis, V; Oliva, P; Rossi, F; Berrino, L; Rossi, F; Maione, S (2001). "Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception". Neuropharmacology 40 (3): 319–26.  
  4. ^ Iserhot, C; Gebhardt, C; Schmitz, D; Heinemann, U (2004). "Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat". Brain Research 1027 (1–2): 151–60.  
  5. ^ Cahusac, PM; Wan, H (2007). "Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo". Neuroscience 146 (1): 202–12.  
  6. ^ Kim, WY; Vezina, P; Kim, JH (2008). "Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment". Behavioural Brain Research 191 (1): 62–6.  
  7. ^ Altinbilek, B; Manahan-Vaughan, D (2009). "A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory". Neuroscience 158 (1): 149–58.  

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