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Title: Eterobarb  
Author: World Heritage Encyclopedia
Language: English
Subject: CGS-8216, CP-615,003, Heptobarbital, Nealbarbital, Procymate
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
Routes Oral
CAS number  YesY
ATC code None
ChemSpider  N
Chemical data
Formula C16H20N2O5 
Mol. mass 320.340 g/mol

Eterobarb (Antilon) is a barbiturate derivative. It has mainly anticonvulsant action with less sedative effects than the closely related compound phenobarbital. It saw reasonable success in clinical trials, but is not in widespread medical use.[1][2]


Eterobarb synthesis, Lednicer book 2

Sodium phenobarbital serves as its own base (so the yield is limited to 50%) and reacts readily with "chloro(methoxy)methane" to produce eterobarb.[3]


  1. ^ Gallagher, BB; Baumel, IP; Woodbury, SG; Dimicco, JA (1975). "Clinical evaluation of eterobarb, a new anticonvulsant drug". Neurology 25 (5): 399–404.  
  2. ^ Smith, DB; Goldstein, SG; Roomet, A (1986). "A comparison of the toxicity effects of the anticonvulsant eterobarb (antilon, DMMP) and phenobarbital in normal human volunteers". Epilepsia 27 (2): 149–55.  
  3. ^ Vida, Julius A. (1971). "Anticonvulsants. 1. Alkoxymethyl derivatives of barbiturates and diphenylhydantoin". Journal of Medicinal Chemistry 14 (3): 187–189.  

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