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Title: Ethotoin  
Author: World Heritage Encyclopedia
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Subject: Primidone, ATC code N03, Valproate pivoxil, Eslicarbazepine acetate, Gabapentin enacarbil
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Structural formula of ethotoin
Ball-and-stick model of the ethotoin molecule
Systematic (IUPAC) name
Clinical data
  • C
Routes of
Pharmacokinetic data
Biological half-life 3 to 9 hours
CAS Registry Number  YesY
ATC code N03
PubChem CID:
DrugBank  YesY
ChemSpider  YesY
Chemical data
Formula C11H12N2O2
Molecular mass


Ethotoin (marketed as Peganone by Ovation) is an anticonvulsant drug used in the treatment of epilepsy. It is a hydantoin, similar to phenytoin. Ethotoin lacks phenytoin's side effects of gingival hyperplasia and hirsutism; however, it is less effective. This, combined with the need for frequent dosing has limited its usefulness. Ethotoin is no longer widely used.


  • Mechanism of action 1
  • Approval history 2
  • Indications and usage 3
  • Dosing 4
  • Side effects 5
  • Chemistry 6
  • References 7
  • External links 8

Mechanism of action

Similar to phenytoin.

Approval history

  • 1957 Peganone was granted Food and Drug Administration (FDA) approval to Abbott Laboratories for treatment of grand mal (tonic clonic) and partial complex (psychomotor) seizures.
  • 2003 Peganone was acquired from Abbott Laboratories by Ovation Pharmaceuticals (specialty pharmaceutical company who acquire underpromoted branded pharmaceutical products).

Indications and usage

Ethotoin is indicated for tonic-clonic and partial complex seizures.


Ethotoin is available in 250mg tablets. It is taken orally in 4 to 6 divided doses per day, preferably after food.

Side effects

Ataxia, visual disturbances, rash and gastrointestinal problems.


Ethotoin, 3-ethyl-5-phenylimidazolidine-2,4-dione, is synthesized by the reaction of benzaldehyde oxynitrile, with urea or ammonium hydrocarbonate, which forms an intermediate urea derivative which on acidic conditions cyclizes to 5-phenylhydantoin. Alkylation of this product using ethyliodide leads to the formation of ethotoin.

  • A. Pinner, Chem. Ber., 21, 2324 (1888).
  • W.J. Close, U.S. Patent 2,793,157 (1946).


  • Ethotoin
  • PEGANONE 250 mg Ethotoin Tablets, USP (PDF)

External links

  • Ovation Pharmaceuticals
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