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Fedotozine

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Fedotozine

Fedotozine
Systematic (IUPAC) name
(2R)-N,N-dimethyl-2-phenyl-1-[(3,4,5-trimethoxybenzyl)oxy]-2-butanamine
Clinical data
Legal status
  • Non-regulated
Routes Oral
Identifiers
CAS number
133267-27-3 (tartrate)
ATC code None
PubChem
ChemSpider
ChEMBL
Chemical data
Formula C22H31NO4 
Mol. mass 373.486 g/mol

Fedotozine (INN; Jo-1196) is an opioid drug of the arylacetamide series which acts as a peripherally-specific, selective κ1-opioid receptor agonist with preference for the κ1A subtype.[1] It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials,[1][2][3] but ultimately development was discontinued and it was never marketed.

See also

References

  1. ^ a b Delvaux M (January 2001). "Pharmacology and clinical experience with fedotozine". Expert Opinion on Investigational Drugs 10 (1): 97–110.  
  2. ^ Barber A, Gottschlich R (October 1997). "Novel developments with selective, non-peptidic kappa-opioid receptor agonists". Expert Opinion on Investigational Drugs 6 (10): 1351–68.  
  3. ^ Lembo A (2006). "Peripheral opioids for functional GI disease: a reappraisal". Digestive Diseases (Basel, Switzerland) 24 (1-2): 91–8.  


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