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Fibroblast growth factor 1

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Title: Fibroblast growth factor 1  
Author: World Heritage Encyclopedia
Language: English
Subject: Implantation (human embryo)
Publisher: World Heritage Encyclopedia

Fibroblast growth factor 1

Fibroblast growth factor 1 (acidic)
PDB rendering based on 1afc.
Available structures
PDB Ortholog search: RCSB
FGF1 Gene
RNA expression pattern

Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene.[1][2]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described.[3]


FGF1 has been shown to interact with CSNK2B,[4] CSNK2A2,[4] HSPA9,[5] S100A13,[6][7] Casein kinase 2, alpha 1,[4] Fibroblast growth factor receptor 1,[8][9] FIBP,[10] Fibroblast growth factor receptor 4,[11][12] Fibroblast growth factor receptor 2[9][13][14] and Fibroblast growth factor receptor 3.[9][15]

See also


Further reading

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