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Title: Gfi1  
Author: World Heritage Encyclopedia
Language: English
Subject: RUNX1T1, Haematopoiesis, Transcription factors, NeuroD, EMX homeogene
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Growth factor independent 1 transcription repressor
Symbols  ; GFI-1; GFI1A; SCN2; ZNF163
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Zinc finger protein Gfi-1 is a protein that in humans is encoded by the GFI1 gene.[1][2]


GFI1 has been shown to interact with PIAS3[3] and RUNX1T1.[4]


  1. ^ Bell DW, Taguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Gilks CB, Zweidler-McKay P, Grimes HL, Tsichlis PN, Testa JR (July 1995). "Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents". Cytogenet Cell Genet 70 (3–4): 263–7.  
  2. ^ "Entrez Gene: GFI1 growth factor independent 1". 
  3. ^ Rödel, B; Tavassoli K; Karsunky H; Schmidt T; Bachmann M; Schaper F; Heinrich P; Shuai K; Elsässer H P; Möröy T (November 2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. (ENGLAND) 19 (21): 5845–55.  
  4. ^ McGhee, Laura; Bryan Josh; Elliott Liza; Grimes H Leighton; Kazanjian Avedis; Davis J Nathan; Meyers Shari (August 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. (United States) 89 (5): 1005–18.  

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