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Galactitol

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Title: Galactitol  
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Subject: Sorbitol, Metabolic intermediate, Volemitol, Ethylene glycol, Fructose
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Galactitol

Galactitol
Identifiers
CAS number  YesY
PubChem
ChemSpider  YesY
ChEBI  YesY
ChEMBL
Jmol-3D images Image 1
Properties
Molecular formula C6H14O6
Molar mass 182.17 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

Galactitol (dulcitol) is a sugar alcohol, the reduction product of galactose.[1] In people with galactokinase deficiency, a form of galactosemia, excess dulcitol forms in the lens of the eye leading to cataracts.[2]

Galactitol is produced from galactose in a reaction catalyzed by aldose reductase. Galactose itself comes from the metabolism of the disaccharide lactose into glucose and galactose.

The other common galactose metabolism defect is a defect in galactose-1-phosphate uridylyltransferase, an autosomal recessive disorder, which also causes a buildup of galactitol as a result of increased concentrations of galactose-1-phosphate and galactose. The toxicity associated with galactose-1-phosphate uridylyltransferase deficiency is associated with symptoms of hepatosplenomegaly and mental retardation in addition to the cataracts caused by galactitol buildup.

References

  1. ^ "Galactitol - Compound Summary".  
  2. ^ Roth, KS (September 10, 2007). "Galactokinase Deficiency".  
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