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Hyperplastic arteriolosclerosis

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Title: Hyperplastic arteriolosclerosis  
Author: World Heritage Encyclopedia
Language: English
Subject: Arteriolosclerosis, Benign hypertension, Vascular malformation, Arterial stiffness, Oxycholesterol
Collection: Vascular Diseases
Publisher: World Heritage Encyclopedia

Hyperplastic arteriolosclerosis

"Onion-skin" renal arteriole

Hyperplastic arteriolosclerosis is a type of arteriolosclerosis involving a narrowed lumen.[1]

The term "onion-skin" is sometimes used to describe this form of vessel [2] with thickened concentric smooth muscle cell layer and thickened, duplicated basement membrane. In malignant hypertension these hyperplastic changes are often accompanied by fibrinoid necrosis of the arterial intima and media. These changes are most prominent in the kidney and can lead to ischemia and acute renal failure.

It can be caused by malignant hypertension.[3]


  1. ^ "hyperplastic arteriolosclerosis" at Dorland's Medical Dictionary
  2. ^ "Pathology Education". Retrieved 2009-01-12. 
  3. ^ "Atherosclerosis". Retrieved 2009-01-12. 
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