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Iodocyanopindolol

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Title: Iodocyanopindolol  
Author: World Heritage Encyclopedia
Language: English
Subject: Cyanopindolol, Revospirone, 5-HT1A receptor, D-161, Sercloremine
Collection: 5-Ht1A Antagonists, Alcohols, Beta Blockers, Indoles, Iodoarenes, Nitriles, Organoiodides, Phenol Ethers
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Iodocyanopindolol

Iodocyanopindolol
Systematic (IUPAC) name
(RS)-4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3-iodo-1H-indole-2-carbonitrile
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code None
ChEBI  N
Chemical data
Formula C16H20IN3O2 
Mol. mass 413.25 g/mol
 N   

Iodocyanopindolol (INN) is a drug related to pindolol which acts as both a β1 adrenoreceptor antagonist and a 5-HT1A receptor antagonist. Its 125I radiolabelled derivative has been widely used in mapping the distribution of beta adrenoreceptors in the body.[1]

References

  1. ^ Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC (1983). "Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding". Circulation Research 53 (6): 752–758.  
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