World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0005512301
Reproduction Date:

Title: Levomethorphan  
Author: World Heritage Encyclopedia
Language: English
Subject: List of opioids, Dextromethorphan, Opioid, Levorphanol, Methorphan
Collection: Enantiopure Drugs, Morphinans, Mu-Opioid Agonists, Phenol Ethers, Prodrugs, Semisynthetic Opioids, Synthetic Opioids
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
Pharmacokinetic data
Biological half-life 3-6 hours
CAS Registry Number  N
ATC code None
PubChem CID:
DrugBank  N
ChemSpider  Y
Chemical data
Formula C18H25NO
Molecular mass 271.397 g/mol

Levomethorphan is the l-stereoisomer of methorphan. The effects of the two isomers are quite different. Dextromethorphan is an antitussive at low doses and a dissociative at much higher doses, whereas levomethorphan is an opioid analgesic. Levomethorphan has effects similar to levorphanol but is less potent as it must be demethylated to the active form by liver enzymes before becoming active. It can therefore be said to be the codeine analogue of levorphanol.

Levomethorphan is listed under the Single Convention On Narcotic Drugs 1961 and is regulated like morphine in most countries. In the United States it is a Schedule II Narcotic controlled substance with a DEA ACSCN of 9210 and 2013 annual aggregate manufacturing quota of 6 grammes. The salts in use are the tartrate (free base conversion ratio 0.64) and hydrobromide (0.77).[1] At the current time, no levomethorphan pharmaceuticals are marketed in the United States.

See also


  1. ^

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.