World Library  
Flag as Inappropriate
Email this Article

Magnolol

Article Id: WHEBN0012029706
Reproduction Date:

Title: Magnolol  
Author: World Heritage Encyclopedia
Language: English
Subject: Lignans, Lignan, Enterodiol, Macelignan, Lariciresinol
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Magnolol

Magnolol[1]
Names
IUPAC name
4-Allyl-2-(5-allyl-2-hydroxy-phenyl)phenol
Other names
Dehydrodichavicol
5,5'-Diallyl-2,2'-dihydroxybiphenyl
5,5'-Diallyl-2,2'-biphenyldiol
Identifiers
 YesY
ChEMBL  N
ChemSpider  N
Jmol-3D images Image
PubChem
Properties
C18H18O2
Molar mass 266.334
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Magnolol is an lignan. It is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis) or in M. grandiflora.[2] The compound exists at the level of a few percent in the bark of species of magnolia, the extracts of which have been used in traditional Chinese and Japanese medicine. In addition to magnolol, related lignans occur in the extracts including honokiol, which is an isomer of magnolol.

Bioactivity

It is known to act on the GABAA receptors in rat cells in vitro[3] as well as having antifungal properties.[4] It is also known to act as agonist of PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2.[5] Magnolol has a number of osteoblast-stimulating and osteoclast-inhibiting activities in cell culture and has been suggested as a candidate for screening for anti-osteoporosis activity.[6] It has anti-periodontal disease activity in a rat model.[7] Structural analogues has been studied and found to be strong allosteric modulators of GABAA.[8]

References

  1. ^ Magnolol at Sigma-Aldrich
  2. ^
  3. ^
  4. ^
  5. ^
  6. ^
  7. ^
  8. ^

Further reading

  • Chaya Venkat, "Sitting under a Magnolia Tree, Mint Julep in Hand" (depicts incorrect structure of magnolol)


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.