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Mepivacaine

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Title: Mepivacaine  
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Subject: Anesthetic, ATC code N01, Local anesthetic, Sodium channel blocker, Cocaine
Collection: Anilides, Local Anesthetics, Piperidines
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Mepivacaine

Mepivacaine
Systematic (IUPAC) name
(RS)-N-(2,6-dimethylphenyl)- 1-methyl-piperidine-2-carboxamide
Clinical data
AHFS/Drugs.com
MedlinePlus
Pregnancy
category
  • C, use w/ caution, may cause fetal bradycardia
Identifiers
CAS Registry Number  Y
ATC code N01
PubChem CID:
IUPHAR/BPS
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
ChEMBL  Y
Chemical data
Formula C15H22N2O
Molecular mass 246.348 g/mol
 Y   

Mepivacaine is a local anesthetic[1] of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine) and is marketed under various trade names including Carbocaine and Polocaine.

Mepivacaine became available in the United States in the 1960s.

Mepivacaine is used in any infiltration and regional anesthesia.

It is supplied as the hydrochloride salt of the racemate.[2]

References

  1. ^ Porto GG, Vasconcelos BC, Gomes AC, Albert D (January 2007). "Evaluation of lidocaine and mepivacaine for inferior third molar surgery" (PDF). Med Oral Patol Oral Cir Bucal 12 (1): E60–4.  
  2. ^ Burm AG, Cohen IM, van Kleef JW, Vletter AA, Olieman W, Groen K (January 1997). "Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers". Anesth. Analg. 84 (1): 85–9.  

External links

  • Mepivacaine at RxList


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