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Title: Mesuximide  
Author: World Heritage Encyclopedia
Language: English
Subject: Primidone, ATC code N03, Ethosuximide, Valproate pivoxil, Eslicarbazepine acetate
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Pregnancy cat.
Legal status
Routes Oral
Pharmacokinetic data
Metabolism Hepatic (demethylation and glucuronidation)
Half-life 1.4–2.6 hours (mesuximide)
28–38 hours (active metabolite)
Excretion Renal
CAS number  YesY
ATC code N03
ChemSpider  YesY
Chemical data
Formula C12H13NO2 
Mol. mass 203.237 g/mol

Mesuximide (or methsuximide, methosuximide) is a succinimide anticonvulsant medication. It is sold as a racemate by Pfizer under the tradenames Petinutin (Switzerland)[1] and Celontin (United States).[2] The therapeutic efficacy of methosuximide is largely due to its pharmacologically active metabolite, N-desmethylmethosuximide, which has a longer half-life and attains much higher plasma levels than its parent.[3]


  1. ^ Pfizer AG (2005). "Petinutin (Mésuximide)". Official Pfizer AG Website (in French). Retrieved August 21, 2006. 
  2. ^ Pfizer Inc. (2008). "Celontin (methsuximide capsules, USP)". Official Pfizer Inc. Website. Retrieved November 21, 2014. 
  3. ^ Porter RJ, Penry JK, Lacy JR, Newmark ME, Kupferberg HJ. Plasma concentrations of phensuximide, methosuximide, and their metabolites in relation to clinical efficacy. Neurology 29: 1509-1513, 1979.

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