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Title: Metharbital  
Author: World Heritage Encyclopedia
Language: English
Subject: Methylphenobarbital, Primidone, 3,3-Diethyl-2-pyrrolidinone, Etazepine, Carisbamate
Collection: Anticonvulsants, Barbiturates, Gabaa Receptor Positive Allosteric Modulators, Imides, Pyrimidinediones
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
CAS Registry Number  Y
ATC code N03
PubChem CID:
DrugBank  Y
ChemSpider  Y
Synonyms Endiemal, metharbitone, methobarbitone[1]
Chemical data
Formula C9H14N2O3
Molecular mass 198.219 g/mol

Metharbital was patented in 1905 by Emil Fischer working for Merck.[2] It was marketed as Gemonil by Abbott Laboratories. It is a barbiturate anticonvulsant, used in the treatment of epilepsy.[3][4] It has similar properties to phenobarbital.


  • 1952 Gemonil was introduced by Abbott Laboratories.
  • 1990 Abbott stopped marketing.


Metharbital can be synthesized from 2,2-diethylmalonic acid and O-methylisourea.[5][6][7]


  1. ^ The Comparative Toxicogenomics Database: Metharbital
  2. ^ US Patent 782742
  3. ^ The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. ISBN 0-632-06046-8
  4. ^ The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5
  5. ^ A. Halpern, J.W. Jones, J. Am. Pharm. Assoc., 38, 352 (1949)
  6. ^ Snyder, J. A.; Link, K. P. (1953). "Preparation and Characterization by Alkaline Methanolysis of 5,5-Diethyl-4-(tetraacetyl-β-D-glucosyloxy)-2,6(1,5)-pyrimidinedione". Journal of the American Chemical Society 75 (8): 1881.  
  7. ^ U.S. Patent 782,742

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